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KMID : 0616120190500040239
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Korean Journal of Pharmacognosy
2019 Volume.50 No. 4 p.239 ~ p.244
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Phenolic Constituents of Boehmeria pannosa and α-Glucosidase Inhibitory Activity
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Ru Se-Hwan
Kim Seon-Beom
Yeon Sang-Won
Turk Ayman
Jo Yang-Hee
Hwang Bang-Yeon
Ahn Mi-Jeong
Lee Mi-Kyeong
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Abstract
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Boehmeria pannosa (Urticaceae) is a perennial herb widely distributed in Korea. In this study, investigation on the constituents of B. pannosa was conducted by chromatographic techniques and spectroscopic analysis. As a result, nine compounds including eight phenolic compounds, 3-hydroxy-1-(4-hydroxyphenyl)propan-1-one (1), b-hydroxypropiovanillone (2), C-veratroylglycol (3), 3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-propan-1-one (4) 2,3-dihydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl) -1-propanone (5), p-coumaric acid (6), 4-hydroxybenzoic acid (7), vanillic acid (8) and one lignan, (-)-(7R,8S)-dihydrodehydrodiconiferyl alcohol (9) were isolated from the EtOAc-soluble fraction of B. pannosa. Among them, compounds 5, 6 and 9 inhibited a-glucosidase inhibitory activity more than 50% at the concentration of 100 μM.
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KEYWORD
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Boehmeria pannosa, a-Glucosidase, Phenolic, Lignan, Diabetes
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